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Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial.
男性包皮环切降低HIV感染风险的随机对照干预试验: 法国国家艾滋病研究署1265试验

PLoS Med. 2005 Nov;2(11):e298. Epub 2005 Oct 25.

Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial.

Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A.

Source

Hopital Ambroise-Paré, Assitance Publique-Hopitaux de Paris, Boulogne, France. bertran.auvert@apr.aphp.fr

Erratum in

  • PLoS Med. 2006 May;3(5):e298.

Abstract

BACKGROUND:

Observational studies suggest that male circumcision may provide protection against HIV-1 infection. A randomized, controlled intervention trial was conducted in a general population of South Africa to test this hypothesis.

METHODS AND FINDINGS:

A total of 3,274 uncircumcised men, aged 18-24 y, were randomized to a control or an intervention group with follow-up visits at months 3, 12, and 21. Male circumcision was offered to the intervention group immediately after randomization and to the control group at the end of the follow-up. The grouped censored data were analyzed in intention-to-treat, univariate and multivariate, analyses, using piecewise exponential, proportional hazards models. Rate ratios (RR) of HIV incidence were determined with 95% CI. Protection against HIV infection was calculated as 1 - RR. The trial was stopped at the interim analysis, and the mean (interquartile range) follow-up was 18.1 mo (13.0-21.0) when the data were analyzed. There were 20 HIV infections (incidence rate = 0.85 per 100 person-years) in the intervention group and 49 (2.1 per 100 person-years) in the control group, corresponding to an RR of 0.40 (95% CI: 0.24%-0.68%; p < 0.001). This RR corresponds to a protection of 60% (95% CI: 32%-76%). When controlling for behavioural factors, including sexual behaviour that increased slightly in the intervention group, condom use, and health-seeking behaviour, the protection was of 61% (95% CI: 34%-77%).

CONCLUSION:

Male circumcision provides a degree of protection against acquiring HIV infection, equivalent to what a vaccine of high efficacy would have achieved. Male circumcision may provide an important way of reducing the spread of HIV infection in sub-Saharan Africa. (Preliminary and partial results were presented at the International AIDS Society 2005 Conference, on 26 July 2005, in Rio de Janeiro, Brazil.).

Comment in

  • PLoS Med. 2005 Nov;2(11):e287.
  • PLoS Med. 2005 Nov;2(11):e293.
  • PLoS Med. 2005 Nov;2(11):e393.
  • PLoS Med. 2006 Jan;3(1):e63; author reply e67.
  • PLoS Med. 2006 Jan;3(1):e64; author reply e67.
  • PLoS Med. 2006 Jan;3(1):e65; author reply e67.
  • PLoS Med. 2006 Jan;3(1):e66; author reply e67.
  • PLoS Med. 2006 Jan;3(1):e75; author reply e7.
  • PLoS Med. 2006 Jan;3(1):e70.
  • PLoS Med. 2006 Jan;3(1):e71; author reply e67.
  • PLoS Med. 2006 Jan;3(1):e72; author reply e67.
  • PLoS Med. 2006 Jan;3(1):e73; author reply e67.
  • PLoS Med. 2006 Jan;3(1):e74; author reply e67.
  • PLoS Med. 2006 Jan;3(1):e78.
PMID: 16231970 [PubMed - indexed for MEDLINE]
PMCID: PMC1262556 Free PMC Article
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