中国商环
Shang Ring

改变了传统的男性包皮环切手术概念


一种更加安全、有效和可接受的男性包皮环切器械和手术方法


欢迎您访问中国商环信息网站!
www.ShangRing.cn
__________________________________________________________________________________________________________________
Abundant expression of HIV target cells and C-type lectin receptors in the foreskin tissue of young Kenyan men
肯尼亚青年男性包皮组织中HIV靶细胞和C型凝集素受体的大量表达
Am J Pathol. 2010 Jun;176(6):2798-805. Epub 2010 Apr 15.

Abundant expression of HIV target cells and C-type lectin receptors in the foreskin tissue of young Kenyan men.

Hirbod T, Bailey RC, Agot K, Moses S, Ndinya-Achola J, Murugu R, Andersson J, Nilsson J, Broliden K.

Source

Center for Molecular Medicine, Infectious Disease Unit, Department of Medicine, Solna, Karolinska Institutet, 171 76 Stockholm, Sweden. taha.hirbod@ki.se

Abstract

A biological explanation for the reduction in HIV-1 (HIV) acquisition after male circumcision may be that removal of the foreskin reduces the number of target cells for HIV. The expression of potential HIV target cells and C-type lectin receptors in foreskin tissue of men at risk of HIV infection were thus analyzed. Thirty-three foreskin tissue samples, stratified by Herpes simplex virus type 2 status, were obtained from a randomized, controlled trial conducted in Kenya. The samples were analyzed by confocal in situ imaging microscopy and mRNA quantification by quantitative RT-qPCR. The presence and location of T cells (CD3(+)CD4(+)), Langerhans cells (CD1a(+)Langerin/CD207(+)), macrophages (CD68(+) or CD14(+)), and submucosal dendritic cells (CD123(+)BDCA-2(+) or CD11c(+)DC-SIGN(+)) were defined. C-type lectin receptor expressing cells were detected in both the epithelium and submucosa, and distinct lymphoid aggregates densely populated with CD3(+)CD4(+) T cells were identified in the submucosa. Although the presence of lymphoid aggregates and mRNA expression of selected markers varied between study subjects, Herpes simplex virus type 2 serostatus was not the major determinant for the detected differences. The detection of abundant and superficially present potential HIV target cells and submucosal lymphoid aggregates in foreskin mucosa from a highly relevant HIV risk group demonstrate a possible anatomical explanation that may contribute to the protective effect of male circumcision on HIV transmission.

PMID:
20395432 [PubMed - indexed for MEDLINE]
PMCID: PMC2877841

 
__________________________________________________________________________________________________________________

| 主 页 | 文献下载 | 相关新闻 | 版权声明 | 联系我们 |

Shang RingTM 和 商环TM芜湖圣大医疗器械技术有限公司的注册商标

网站设计与维护:南京埃利希生物技术有限责任公司 版权所有

苏ICP备11018658号